Zeolite-Clinoptilolite Study
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STUDY
Natural zeolite clinoptilolite: new adjuvant in
anticancer therapy.
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Natural silicate materials, including zeolite
clinoptilolite, have been shown to exhibit diverse biological
activities and have been used successfully as a vaccine adjuvant and for
the treatment of diarrhea. We report a novel use of finely ground
clinoptilolite as a potential adjuvant in anticancer therapy.
Clinoptilolite treatment of mice and dogs suffering from a variety of
tumor types led to improvement in the overall health status, prolongation
of life-span, and decrease in tumors size. Local application of
clinoptilolite to skin cancers of dogs effectively reduced tumor formation
and growth. In addition, toxicology studies on mice and rats demonstrated
that the treatment does not have negative effects. In vitro tissue culture
studies showed that finely ground clinoptilolite inhibits protein kinase B
(c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor
proteins, and blocks cell growth in several cancer cell lines. These data
indicate that clinoptilolite treatment might affect cancer growth by
attenuating survival signals and inducing tumor suppressor genes in
treated cells.
Ruder Boskovic Institute, Division of Molecular
Medicine, Zagreb, Croatia. pavelic@rudjer.irb.hr
Authors/Credit:
Pavelic K, Hadzija M, Bedrica L, Pavelic J,
Dikic I, Katic M, Kralj M, Bosnar MH, Kapitanovic S, Poljak-Blazi M,
Krizanac S, Stojkovic R, Jurin M, Subotic B, Colic M.
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